Fernando de Mello Franco is one of the founding partners of MMBB Arquitetos in São Paulo, Brazil. He was a visiting professor at Harvard. De Mello Franco has strong ties with the IABR. In 2007 he won the Biennale Award with the project Watery Voids. In the 4th IABR, in 2009, he was one of the designers working on the project in the favela Paraisópolis that was set up as a collaboration of the IABR and SEHAB, the Municipality of São Paulo's Social Housing Department.
In 2012 he was a member of the international Curator Team of the 5th IABR: Making City and in that capacity he was the Atelier Master of the Atelier São Paulo, an initiative of the IABR and SEHAB in the context of the IABR Test Site São Paulo.
Fernando de Mello Franco was the Secretary of Urban Development of the City of São Paulo from 2013 until 2016, after which he became, among others, a Director of URBEM (Instituto de Urbanismo e Estudos para a Metrópole).